SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with SofosbuvirArticle Published on 2022-11-032022-11-15 Journal: PLoS Biology [Category] SARS, 치료제, [키워드] accompanied Affect alleviate alteration Antiviral antivirals Brain brain organoid brain organoids cell death cells cellular coronavirus 2 coronavirus disease cortical COVID-19 death determine drug excitatory food infect inhibit SARS-CoV-2 neurological manifestation Neurological symptoms neuronal neurons Newborn pandemic phenotype promote replicate Replication rescued respiratory respiratory illnesses SARS-CoV-2 sofosbuvir Treatment underlie variety WHO World Health Organization [DOI] 10.1371/journal.pbio.3001845 PMC 바로가기
Cotton flower metabolites inhibit SARS-CoV-2 main proteaseArticle Published on 2022-10-012022-11-15 Journal: FEBS Open Bio [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome anti-SARS-CoV-2 Antiviral assays biochemical biochemical assay contagious coronavirus cotton cotton flower database disease drugs effective examined exhibited half-maximal inhibitory concentration IC50s identify in vitro inhibit SARS-CoV-2 inhibited inhibitor inhibitory effect M pro main protease metabolite protease Protein safety profile SARS-CoV-2 significantly Spread tissue Treatment Vaccine variants Virtual screening virtual screening. [DOI] 10.1002/2211-5463.13477 PMC 바로가기
Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2Article Published on 2022-10-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome addition Analysis binding affinity block Calu-3 caused cell entry complementary coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients docking drug energy transfer evade exhibit Fritillaria functional glycoprotein Hydrogen bond Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction lung cells molecular docking analysis N501Y patients peimine. Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral infection significantly small molecule suggested suppresse the spike protein treatment for COVID-19 Vaccine variant variant spike variants of concern variants of SARS-CoV-2 viral entry viral infection viral infections viral spike viral spike protein VoC VOCs [DOI] 10.1111/jfbc.14354 PMC 바로가기
Could Endogenous Glucocorticoids Influence SARS-CoV-2 Infectivity?Article Published on 2022-09-212022-11-15 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 (angiotensin converting enzyme 2) Affect alteration analogues Antiviral component conformational coronavirus coronavirus diseases cortisol COVID-19 Deleterious Dexamethasone endogenous enzyme glucocorticoid Glucocorticoids groups Host Immunological disorders Infection influence inhibit SARS-CoV-2 Innate immunity Interaction mechanism outcome pathogen produced PROTECT Protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signal transduction spike Spike protein spike protein. stimulate subunit surface protein target cells variant [DOI] 10.3390/cells11192955 PMC 바로가기
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 modelArticle Published on 2022-09-062022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] Activation animal model antiviral property ciliated cells COVID-19 disease epithelial Factor FG-4592 Host hypoxia hypoxic identify increased expression Infection Infectious virus inhibit SARS-CoV-2 inhibitor intrinsic Lower respiratory tract lung epithelia microenvironment nucleocapsid expression pathological analysis pathway provide reduced reduction in regulate respiratory pathogen respiratory symptom SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA significantly susceptibility therapeutic Therapies transcriptional treated understanding virus replication [DOI] 10.1371/journal.ppat.1010807 PMC 바로가기
New Chemicals Suppressing SARS-CoV-2 Replication in Cell CultureArticle Published on 2022-09-052022-11-15 Journal: Molecules [Category] SARS, 치료제, [키워드] antiviral drug binding calculated candidate Cell Cell culture Chemical Compound coronavirus cytotoxicity database derivatives develop docked docking EC50 value experiment experiments inhibit SARS-CoV-2 inhibitor inhibitors Ligand main protease molecular MPro New protease protein-ligand quantum chemistry. Replication SARS-CoV-2 SARS-CoV-2 replication selected Selection Seven solvent state suppressed Suppressing the SARS-CoV-2 university Vero E6 [DOI] 10.3390/molecules27175732 PMC 바로가기
Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In VivoArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 affected approach block comparable decoy receptors dimeric effective Efficiency escape mutations fused greater in vivo inhibit SARS-CoV-2 isolates monoclonal antibodies monomeric MoonTag multimerization Mutation mutations neutralization neutralized Neutralizing offer provide sACE2 sACE2. SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SunTag Therapeutic treatment Treatment trimeric unlikely variants of concern [DOI] 10.1002/advs.202201294 PMC 바로가기
Targeted escape of SARS-CoV-2 in vitro from monoclonal antibody S309, the precursor of sotrovimabArticle Published on 2022-08-242022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] ACE2 ACE2 binding ACE2 binding site Amino acid angiotensin-converting enzyme 2 antibody Cell cell entry class conserved domain endocytosis Entry epitope escaped Evolution Evolution of SARS-CoV-2 fusion immune Immune escape immunological in vitro infections inhibit SARS-CoV-2 Interaction monoclonal monoclonal antibody not affected pathogenicity plasticity precursor Receptor-binding domain replicated S309 SARS-CoV-2 Sotrovimab. susceptible the spike protein vaccination viral strain wild-type SARS-CoV-2 [DOI] 10.3389/fimmu.2022.966236 PMC 바로가기
Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2SARS-CoV-2에 대한 구강 세정제 중 염화세틸피리디늄의 항바이러스 효과Article Published on 2022-08-182022-09-11 Journal: Scientific Reports [Category] SARS, 진단, 치료제, [키워드] Alpha Ammonium Analysis anti-SARS-CoV-2 Antiviral effect Bacteria Beta Cetylpyridinium cetylpyridinium chloride chloride Concentration concentrations conducted demonstrated disrupting Effect effective experimental evidence fungi Gamma Infection inhibit SARS-CoV-2 microscopic examination Mouthwash provided Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain sucrose suppressed virus viruses wild-type SARS-CoV-2 Wuhan [DOI] 10.1038/s41598-022-18367-6 PMC 바로가기 [Article Type] Article
Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo생체 내에서 오미크론, 델타 SARS-CoV-2 변이체 및 인플루엔자 A 바이러스에 대한 펩티드 결함 간섭 유전자 나노입자Article Published on 2022-08-032022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 변종, 신종인플루엔자, 치료제, [키워드] A549 A549 cells airway Alpha Antiviral Cell Delta demonstrated dose drug delivery system gene delivery Gene Expression Gene therapy in vivo Influenza influenza A virus Influenza virus inhibit inhibit SARS-CoV-2 interfere lung Lungs mice omicron Omicron variants peptide-based prophylactically PROTECT provide Replication replication of SARS-CoV-2 respiratory tract respiratory viruses SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants significantly variant viral challenge viral genome viral replication virus wild-type [DOI] 10.1038/s41392-022-01138-0 PMC 바로가기 [Article Type] Article